The effect of hydrochlorothiazide on the recurrence of nonmelanoma skin cancer: a 7-year retrospective study comprising 300 patients

Background/aim: Hydrochlorothiazide (HCTZ) possesses well-described photosensitizing properties, and a causal association with nonmelanoma skin cancer (NMSC) was recently shown. However, previous studies have not shown whether HCTZ use is associated the risk of recurrence basal cell carcinoma (BCC) or squamous (SCC). This study aims to investigate between in patients NMSC. Materials methods: We identified cases NMSC from our hospital archives during period 2013 2019. Patients were divided into groups according pathological diagnosis, use, recurrence. Multivariable analysis performed determine factors BCC SCC. Results: Recurrences significantly higher users ORs 4.839221 (95% confidence interval [CI], 1.22-19.12). In users, increased age (p < 0.001 for both SCC). recurrences statistically significant age, longer follow-up, positive margins after excision = 0.048, 0.020, and, 0.003, respectively). SCC use. Conclusion: recurrences. Especially elderly population, margin should be followed closely.